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Therapeutic Targeting of DNA Damage Response Pathways in TP53 - and ATM -Mutated Tumors

1 Jan 2025

Abstract excerpt

Mutations in tumor protein p53 (TP53) and ataxia telangiectasia mutated (ATM) genes are frequently observed across various solid and hematologic malignancies and are associated with genomic instability, treatment resistance, and poor clinical outcomes.These alterations compromise the G1/S cell cycle checkpoint and increase cellular dependence on compensatory DNA damage response (DDR) pathways, including the...

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PMID: 40759474
DOI: 10.14791/btrt.2025.0017

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