Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy.

Current drug targets - 1 Jan 2016

Vecchio Donatella, Frosina Guido

Abstract excerpt

Genotoxic anticancer drugs explicate their effects damaging DNA, thus triggering a coordinated signal-transduction network called DNA Damage Response (DDR). Ataxia Telangiectasia Mutated (ATM) protein plays a central role in this response: activated by DNA damage, ATM phosphorylates itself and downstream effectors that arrest cell cycle allowing for DNA repair or, should DNA damage be too severe and not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Ataxia Telangiectasia Mutated Proteins
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ATM gene

Share to Molecular Targeted Therapy

Share to Mutation

Share to Neoplasms

Share to Small Molecule Libraries

Source

Identifiers

PMID: 25382204
DOI: 10.2174/1389450115666141110154621

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy.PMID 25382204Read ↗

Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach.Semantic proximity Read ↗

Clinical potential of ATM inhibitors.Semantic proximity Read ↗

Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.Semantic proximity Read ↗

ATM Mutations in Cancer: Therapeutic Implications.Semantic proximity Read ↗

Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications.Semantic proximity Read ↗

ATM and ATR as therapeutic targets in cancerSemantic proximity Read ↗

Targeting the DNA damage response in cancerSemantic proximity Read ↗

The role of ATM in DNA damage responses and cancer.Semantic proximity Read ↗

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA DamageSemantic proximity Read ↗

Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large OrchestraSemantic proximity Read ↗

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA DamageSemantic proximity Read ↗

Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.