Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer.

doi:10.1016/j.chom.2026.02.006

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Article

Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer.

Cell host & microbe - 11 Mar 2026

Sorrenti Elisa, Governa Valeria, Bressan Davide, Cremonesi Eleonora, Formaggio Nicolò, Latino Irene, Calì Bianca, Torcasio Cristina, Basso Camilla, Galafassi Jacopo, Villa Martina, Stornante Carla, Cetti Federica, Calabrese Diego, Ercan Caner, Mauri Federica, Terzaghi Laura, Mele Valentina, Poncioni Elisa, Djordjevic Julija, Cianfarani Agnese, Tonolla Mauro, Sconocchia Giuseppe, Janssen Klaus-Peter, Frattini Milo, Theurillat Jean-Philippe, Gonzalez Santiago F, De Dosso Sara, Eppenberger-Castori Serenella, Terracciano Luigi Maria, Majno-Hurst Pietro Edoardo, Chiacchiera Fulvio, Borsig Lubor, Spagnoli Giulio Cesare, Christoforidis Dimitrios, Iezzi Giandomenica

Abstract excerpt

The role of tumor-associated neutrophils (TANs) infiltrating colorectal cancers (CRCs) is still debated. Here, we unravel that TAN recruitment and functions are modulated by intratumoral microbiota and only defined bacterial species can unleash neutrophil cytotoxic potential. Fusobacterium nucleatum promotes the production of neutrophil-recruiting chemokines by tumor cells and enhances neutrophil migration more...

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PMID: 41819084
DOI: 10.1016/j.chom.2026.02.006

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