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Article

Multi ancestry genome wide association meta analysis of urinary aMT6s levels.

Scientific reports - 22 Apr 2026

Żebrowska Magdalena, Zhang Ziwei, Chuang Gwo-Tsann, Evans Daniel S, Valliere Jesse, Maher Matthew, Hu Jie, Richmond Rebecca, Turman Constance, Hart Jaime E, Lane Jacqueline, Marchand Loic Le, Wilkens Lynne, Wielscher Matthias, Haiman Christopher, Cheng Iona, Eliassen A Heather, Stone Katie L, Tranah Gregory J, Chang Yi-Cheng, Mucci Lorelei Ann, Schernhammer Eva S, Saxena Richa

Abstract excerpt

Melatonin regulates circadian rhythms, metabolism, and immunity. Its primary metabolite, 6-sulfatoxymelatonin (aMT6s), is a biomarker linked to cancer risk and metabolic disorders. However, genetic determinants of aMT6s remain poorly understood, with only one prior GWAS limited to an East Asian cohort. We conducted the first multi-ancestry genome-wide association meta-analysis of urinary aMT6s, integrating 11,744...

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Identifiers

PMID: 42020658
DOI: 10.1038/s41598-026-49491-2
PMCID: PMC13269534

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