Article
Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations.
Cardiovascular diabetology - 24 Mar 2026
Ding Yilan, Lin Hong, Yin Yue, Li Mian, Xu Yu, Wang Shuangyuan, Xu Min, Zheng Jie, Wang Tiange, Zhao Zhiyun, He Xiadi, Liu Ruixin, Qiao Hong, Qin Guijun, Qin Yingfen, Tang Xulei, Ye Zhen, Hu Ruying, Shi Lixin, Su Qing, Yu Xuefeng, Yan Li, Wan Qin, Chen Gang, Gao Zhengnan, Wang Guixia, Shen Feixia, Gu Xuejiang, Luo Zuojie, Chen Li, Hou Xinguo, Huo Yanan, Li Qiang, Zhang Yinfei, Zeng Tianshu, Liu Chao, Wang Youmin, Wu Shengli, Yang Tao, Deng Huacong, Li Donghui, Lai Shenghan, Chen Lulu, Zhao Jiajun, Mu Yiming, Ning Guang, Wang Weiqing, Bi Yufang, Lu Jieli
Abstract excerpt
BACKGROUND: The genetic architecture of circulating amino acids (AAs) and microbiota-related metabolites (MRMs) in relation to cardiometabolic disease remains poorly characterized in East Asian populations, limiting ancestry-specific insights. METHODS: In a prospective cohort of 2953 Chinese individuals, we performed a large-scale genome-wide association study (GWAS) of 28 serum AAs and 22 MRMs. We conducted a...
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