Article
Mutations in bdcA and valS Correlate with Quinolone Resistance in Wastewater Escherichia coli.
International journal of molecular sciences - 4 Jun 2021
Malekian Negin, Al-Fatlawi Ali, Berendonk Thomas U, Schroeder Michael
Abstract excerpt
Single mutations can confer resistance to antibiotics. Identifying such mutations can help to develop and improve drugs. Here, we systematically screen for candidate quinolone resistance-conferring mutations. We sequenced highly diverse wastewater E. coli and performed a genome-wide association study (GWAS) to determine associations between over 200,000 mutations and quinolone resistance phenotypes. We uncovered...
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