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Article

Uncovering novel germline variants associated with testicular germ cell tumors by exome sequencing.

NAR cancer - 1 Jun 2026

Cuevas-Estrada Berenice, Ríos-Rodríguez Juan A, García-Pacheco José A, Wegman-Ostrosky Talia, Cervera Alejandra, Alcaraz Nicolas, Montalvo-Casimiro Michel, Barrón-Hernández Alejandra, Castro-Hernández Clementina, Jiménez-Ríos Miguel A, Sobrevilla-Moreno Nora, Arriaga-Canon Cristian, Herrera Luis A, González-Barrios Rodrigo

Abstract excerpt

Testicular germ cell tumors (TGCT) are highly heritable malignancies that display increasing incidence worldwide, with rising mortality rates particularly evident among Hispanic men. However, genomic studies of TGCT have largely focused on European cohorts, limiting accurate risk prediction in other populations. We investigated rare germline variants contributing to TGCT susceptibility in a Hispanic cohort. Exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

Share to Polymorphism, Single Nucleotide

Share to Testicular Neoplasms

Source

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Identifiers

PMID: 42017013
DOI: 10.1093/narcan/zcag007
PMCID: PMC13092976

Genes

ARFGAP1
CAPN8
MAP3K5
MC4R
SLCO4A1
VAV2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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