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Article

HIV immunological nonresponders show low SKAP1 concentration and DNA hypermethylation in the SKAP1 promotor region.

AIDS (London, England) - 1 Sept 2026

Vos Wilhelm A J W, Ruijten Suzanne D E, Jiang Xun, van Unen Nienke, van Snippenberg Willem, Groenendijk Albert L, Blaauw Marc J T, van Eekeren Louise E, Vadaq Nadira, Maas Hanneke, Östman Malin, Cleophas Maartje C P, Brinkman Kees, van Lunzen Jan, Blok Willem L, Stalenhoef Janneke E, Li Yang, Netea Mihai G, Vandekerckhove Linos, Dos Santos Jéssica C, Matzaraki Vasiliki, Xu Cheng-Jian, van der Ven Andre J A M

Abstract excerpt

OBJECTIVE: The aim of this study was to improve understanding of biological pathways underlying inadequate CD4 + T-cell restoration after initiating antiretroviral treatment as these so called Immunological nonresponders are at increased risk for morbidity and mortality while treatment options are lacking. DESIGN: We compared baseline multiomics data from 88 Immunological nonresponders and 1467 immunological...

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CD4-Positive T-Lymphocytes
DNA Methylation
CD4 gene
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Source

Identifiers

PMID: 42013451
DOI: 10.1097/QAD.0000000000004529

Genes

SKAP1
CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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