Article
T-cell signalling in antiretroviral-treated, aviraemic HIV-1-positive individuals is present in a raised state of basal activation that contributes to T-cell hyporesponsiveness.
AIDS (London, England) - 23 Oct 2011
Downey Jocelyn S, Attaf Meriem, Moyle Graeme, Gazzard Brian, Gotch Frances, Imami Nesrina
Abstract excerpt
OBJECTIVE: Successful antiretroviral therapy (ART) suppresses plasma HIV-1 RNA below detection limits, reducing the chronic insult to the immune systems of infected individuals and supporting a degree of immunological recovery. However, the surface phenotypic profile of T cells in ART-treated patients does not resemble that of healthy, uninfected individuals, but rather shows upregulation of proteins associated...
Topics
- Adult
- Aged
- Anti-HIV Agents
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Extracellular Signal-Regulated MAP Kinases
- Female
- Flow Cytometry
- HIV Infections
- HIV-1
- Humans
- Lymphocyte Activation
- Male