Article
Connecting HTT intermediate alleles and microRNA dysregulation to enhanced tauopathy in late-onset Alzheimer's disease.
Alzheimer's research & therapy - 20 Apr 2026
Castilla-Silgado Juan, Perez-Oliveira Sergio, Pinto-Hernandez Paola, Fernandez-Sanjurjo Manuel, Corte-Torres Maria Daniela, Fernandez-Alvarez Olaya, Iglesias-Gutierrez Eduardo, Menendez-Gonzalez Manuel, Alvarez Victoria, Tomas-Zapico Cristina
Abstract excerpt
BACKGROUND: Late-onset Alzheimer´s disease (LOAD) is a heterogeneous disorder influenced by complex genetic factors. We previously described intermediate alleles (IAs; 27–35 CAG repeats) in the huntingtin (HTT) gene as potential modifiers in around 6% of AD population. The caudate nucleus, the most affected region in Huntington’s disease, is highly sensitive to these HTT CAG repeats. We hypothesized that HTT IAs...
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