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Synergistic impact of CAG intermediate alleles in the<i>HTT</i>gene and microRNA dysregulation exacerbates spliceosome impairment and accelerates Tau pathology in the caudate nucleus of late-onset Alzheimer’s disease

2025-01-19

Abstract excerpt

<h4>Background</h4> Late-onset Alzheimer’s disease (LOAD) accounts for more than 95% of AD cases. Previously, we have described that 6% of AD patients present CAG intermediate alleles in the huntingtin gene ( HTT IA s). The caudate nucleus, the most affected region in Huntington’s disease, is highly sensitive to these HTT CAG expansions, as they can induce epigenetic changes, including altered microRNA profiles. A...

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Literature Corpus work
ade47760-7c98-5e41-9219-b0739f7dea2f
DOI
10.1101/2025.01.19.25320764
Open publication

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Synergistic impact of CAG intermediate alleles in the<i>HTT</i>gene and microRNA dysregulation exacerbates spliceosome impairment and accelerates Tau pathology in the caudate nucleus of late-onset Alzheimer’s diseaseDOI 10.1101/2025.01.19.25320764
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