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Article

Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients.

Scientific reports - 14 Jan 2020

Dai Yuanyuan, Amenov Asset, Ignatyeva Nadezda, Koschinski Andreas, Xu Hang, Soong Poh Loong, Tiburcy Malte, Linke Wolfgang A, Zaccolo Manuela, Hasenfuss Gerd, Zimmermann Wolfram-Hubertus, Ebert Antje

Abstract excerpt

The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation-contraction coupling, sarcomeric stability and force generation. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein misalignment and impaired contractility. Yet it is not known how TnT...

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Identifiers

PMID: 31937807
DOI: 10.1038/s41598-019-56597-3
PMCID: PMC6959358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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