Article
Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis.
Cancer discovery - 1 Jul 2020
Kato Shinichiro, Weng Qing Yu, Insco Megan L, Chen Kevin Y, Muralidhar Sathya, Pozniak Joanna, Diaz Joey Mark S, Drier Yotam, Nguyen Nhu, Lo Jennifer A, van Rooijen Ellen, Kemeny Lajos V, Zhan Yao, Feng Yang, Silkworth Whitney, Powell C Thomas, Liau Brian B, Xiong Yan, Jin Jian, Newton-Bishop Julia, Zon Leonard I, Bernstein Bradley E, Fisher David E
Abstract excerpt
Epigenetic regulators, when genomically altered, may become driver oncogenes that mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus, such as activation of the WNT/β-catenin pathway in melanoma. This study identifies previously unrecognized recurrent activating mutations in the G9a histone methyltransferase gene, as well as G9a genomic copy gains in approximately 26% of human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.