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Article

Oocyte gene mutations increase rates of total fertilization failure: a systematic review and meta-analysis.

Reproductive biology and endocrinology : RB&E - 18 Apr 2026

Kepkep Begüm, Botos Máté Szabolcs, Yazıcı İpek, Frivaldszky Lőrinc, Rancz Anett, Hegyi Péter, Ács Nándor, Melczer Zsolt, Szentes Boglárka, Sipos Miklós

Abstract excerpt

INTRODUCTION: Total fertilization failure (TFF) remains a critical barrier in assisted reproductive technology (ART), occurring in 5–10% of treatment cycles. While TFF can result from both male and female gamete factors, emerging evidence suggests that oocyte gene mutations may play a significant role. This study systematically reviews and meta-analyzes the influence of specific oocyte gene mutations (OGMs) on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42001136
DOI: 10.1186/s12958-026-01546-9
PMCID: PMC13227840

Genes

PATL2
TUBB8
WEE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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