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Novel mutations in WEE2: Expanding the spectrum of mutations responsible for human fertilization failure

10 Jan 2019

Abstract excerpt

Successful fertilization is fundamental for sexual reproduction. After undergoing a series of molecular and morphological changes, the haploid sperm fuses with the haploid oocyte to create a diploid zygote. Defects in this process might lead to human fertilization failure. We have previously found homozygous mutations in WEE2 that are responsible for human fertilization failure, but the genetic basis of human...

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PMID: 30628060
DOI: 10.1111/cge.13505

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