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Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation

28 Mar 2023

Abstract excerpt

BACKGROUND: Total fertilization failure (TFF) is the failure of all metaphase II oocytes to fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1-3% of ICSI cycles. Oocyte activation deficiency (OAD) is the leading cause of fertilization failure, attributed to sperm- or oocyte-related issues, although until recently little attention has been given to oocyte-related...

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PMID: 36977357
DOI: 10.1093/humupd/dmad007

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