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Article

Mutational disruption of transcription factors binding and regulatory networks in a case of unexplained total fertilization failure.

Journal of translational medicine - 4 Nov 2025

Ata Manar, Choucair Fadi, Djekidel Mohamed Nadhir, Sousa Esteves Maria, Al Ali Fatima, Nawaz Shoaib, El Taha Lina, Soloviov Oleksandr, Sathappan Abbirami, Aliyev Elbay, Fakhro Khalid, Awwad Johnny, Avella Matteo A

Abstract excerpt

BACKGROUND: Fertilization involves fusion between sperm and metaphase II (MII) oocyte, initiating a cascade of events including oocyte activation, resumption of meiosis, formation and interdigitation of male and female pronuclei, and zygote formation. Total Fertilization Failure (TFF), characterized by the disruption of any of these processes, occurs in 1-3% of intracytoplasmic sperm injection (ICSI) cycles. The...

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Topics

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Share to Fertilization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oocytes

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Source

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Identifiers

PMID: 41188932
DOI: 10.1186/s12967-025-07038-5
PMCID: PMC12584518

Genes

ZFP28
ZNF121
SP2
VEZF1
YY1
TFAP2D
ZNF148
ZNF260
ZNF394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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