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Article

High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI

1 Jan 2024

Abstract excerpt

Abstract STUDY QUESTION What is the frequency of PLCZ1, ACTL7A, and ACTL9 variants in male patients showing fertilization failure after ICSI, and how effective is assisted oocyte activation (AOA) for them? SUMMARY ANSWER Male patients with fertilization failure after ICSI manifest variants in PLCZ1 (29.09%), ACTL7A (14.81%), and ACTL9 (3.70%), which can be efficiently overcome by AOA treatment with ionomycin....

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Identifiers

PMID: 39411542
DOI: 10.1093/hropen/hoae057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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