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Article

Cluster assembly dynamics drive fidelity of planar cell polarity polarization.

Nature communications - 18 Apr 2026

Nissen Silas Boye, Weiner Alexis T, Suyama Kaye, Bosch Pablo Sanchez, Yu Maiya, Song Song, Gu Yuan, Dunn Alexander R, Axelrod Jeffrey D

Abstract excerpt

Planar cell polarity (PCP) signaling orients epithelial cells along an in-plane tissue axis and is a required feature of embryonic development in bilaterians. In PCP signaling, distinct molecular subcomplexes segregate to opposite sides of each cell, where they interact across intercellular junctions to form highly polarized clusters. How signal amplification and error correction occur to achieve the observed...

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PMID: 42000757
DOI: 10.1038/s41467-026-71839-5
PMCID: PMC13275883

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