Article
Variation in genomic landscape of clear cell renal cell carcinoma across Europe.
Nature communications - 29 Oct 2014
Scelo Ghislaine, Riazalhosseini Yasser, Greger Liliana, Letourneau Louis, Gonzàlez-Porta Mar, Wozniak Magdalena B, Bourgey Mathieu, Harnden Patricia, Egevad Lars, Jackson Sharon M, Karimzadeh Mehran, Arseneault Madeleine, Lepage Pierre, How-Kit Alexandre, Daunay Antoine, Renault Victor, Blanché Hélène, Tubacher Emmanuel, Sehmoun Jeremy, Viksna Juris, Celms Edgars, Opmanis Martins, Zarins Andris, Vasudev Naveen S, Seywright Morag, Abedi-Ardekani Behnoush, Carreira Christine, Selby Peter J, Cartledge Jon J, Byrnes Graham, Zavadil Jiri, Su Jing, Holcatova Ivana, Brisuda Antonin, Zaridze David, Moukeria Anush, Foretova Lenka, Navratilova Marie, Mates Dana, Jinga Viorel, Artemov Artem, Nedoluzhko Artem, Mazur Alexander, Rastorguev Sergey, Boulygina Eugenia, Heath Simon, Gut Marta, Bihoreau Marie-Therese, Lechner Doris, Foglio Mario, Gut Ivo G, Skryabin Konstantin, Prokhortchouk Egor, Cambon-Thomsen Anne, Rung Johan, Bourque Guillaume, Brennan Paul, Tost Jörg, Banks Rosamonde E, Brazma Alvis, Lathrop G Mark
Abstract excerpt
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. Our...
Read the complete abstract on PubMed