Article
Correlation of structural elements and infectivity of the HET-s prion.
Nature - 9 Jun 2005
Ritter Christiane, Maddelein Marie-Lise, Siemer Ansgar B, Lührs Thorsten, Ernst Matthias, Meier Beat H, Saupe Sven J, Riek Roland
Abstract excerpt
Prions are believed to be infectious, self-propagating polymers of otherwise soluble, host-encoded proteins. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in t...
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