Extensive peripheral immune cell phenotypes and nephrotic syndrome: Tracing causality through genetics - a bilateral Mendelian randomization study.

Abstract excerpt

Nephrotic syndrome (NS) is a complex renal disorder characterized by significant proteinuria, hypoalbuminemia, and hyperlipidemia. While its etiology involves genetic and environmental factors, the role of the immune system in NS's pathogenesis remains incompletely understood. We adopted a bilateral Mendelian randomization approach, leveraging genetic variations as proxies to explore the causality between immune...

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