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Article

Mendelian randomization based on immune cells in diabetic nephropathy.

Frontiers in endocrinology - 1 Jan 2024

Zhou Ye, Zhang Hengyan, Yan Heguo, Huang Changxing, Liu Yangwen

Abstract excerpt

Background: DKD, a leading cause of chronic kidney and end-stage renal disease, lacks robust immunological research. Recent GWAS utilizing SNPs and CNVs has shed light on immune mechanisms of kidney diseases. However, DKD's immunological basis remains elusive. Our goal is to unravel cause-effect relationships between immune cells and DKD using Mendelian randomization. Methodology: We analyzed FinnGen data (1032...

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Identifiers

PMID: 39165512
DOI: 10.3389/fendo.2024.1460652
PMCID: PMC11333325

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