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Article

Immune cell phenotypes in the context of diabetic nephropathy: A Mendelian randomization analysis.

Medicine - 3 Jul 2026

Tong Keke, Deng Juan, Yu Yunfeng, Xiang Qin, Wu Jingyi, Pan Weili, Huang Juan

Abstract excerpt

To clarify whether specific immune cell phenotypes exert a causal influence on diabetic nephropathy (DN), we conducted a Mendelian randomization (MR) investigation using large-scale genetic datasets. Summary-level data for immune cell traits and DN were obtained from recent genome-wide association studies and the FinnGen consortium. Genetic instruments were selected under the core MR assumptions, ensuring strong...

Topics

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Diabetic Nephropathies
CD14 gene
CD4 gene
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 42410796
DOI: 10.1097/MD.0000000000049443
PMCID: PMC13336965

Genes

CD4
CD14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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