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Article

Intersection of phenotypic plasticity and anoikis enhances therapeutic vulnerability in prostate cancer.

Endocrinology - 7 Apr 2026

Kouspou Maria, Zhu Alec, Martires Lauren, Tewari Ashutosh K, Mehrazin Reza, Kyprianou Natasha

Abstract excerpt

During cancer metastasis, tumor cells survive in circulation by acquiring resistance to anoikis. Restoring vulnerability of cancer cells to anoikis can impair metastatic colonization, minimize treatment resistance, and tumor recurrence in patients. A compelling body of evidence has identified strategies for the development of effective inhibitors that can block survival pathways such as FAK, PI3K/AKT, MAPK and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41992725
DOI: 10.1210/endocr/bqag046

Genes

CDKN1A
JAM2
NEDD9
CFL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Intersection of phenotypic plasticity and anoikis enhances therapeutic vulnerability in prostate cancer.PMID 41992725Read ↗

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