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Article

Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response.

Oncogene - 1 Dec 2025

Nepali Prerna R, Gonzalez-Kozlova Edgar, Anegondi Maitri, Dogra Navneet, Archer Maddison, Chakraborty Goutam, Tewari Ashutosh K, Hopkins Benjamin D, Kyprianou Natasha

Abstract excerpt

Epithelial mesenchymal transition (EMT) circumvents anoikis (cell death upon detachment from extracellular matrix) to promote prostate metastasis and therapy resistance. In this study, we investigated how TGF-β regulated EMT-MET (mesenchymal epithelial transition) phenotypic interconversions to enhance anoikis response in pre-clinical models of prostate cancer (PCa). We used human PCa cell line models: VCaP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41275067
DOI: 10.1038/s41388-025-03600-z
PMCID: PMC12669019

Genes

MET
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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