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Article

Comparative genomic and transcriptomic analyses of LNCaP and C4-2B prostate cancer cell lines.

PloS one - 1 Jan 2014

Spans Lien, Helsen Christine, Clinckemalie Liesbeth, Van den Broeck Thomas, Prekovic Stefan, Joniau Steven, Lerut Evelyne, Claessens Frank

Abstract excerpt

The LNCaP and C4-2B cell lines form an excellent preclinical model to study the development of metastatic castration-resistant prostate cancer, since C4-2B cells were derived from a bone metastasis that grew in nude mice after inoculation with the LNCaP-derived, castration-resistant C4-2 cells. Exome sequencing detected 2188 and 3840 mutations in LNCaP and C4-2B cells, respectively, of which 1784 were found in...

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Identifiers

PMID: 24587179
DOI: 10.1371/journal.pone.0090002
PMCID: PMC3938550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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