Article

Disassembly of hemidesmosomes promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions

2021-11-08

Abstract excerpt

Loss of α6β4-dependent hemidesmosomes has been observed during prostate cancer progression. However, the significance and underlying mechanisms by which aberrant hemidesmosome assembly may modulate tumorigenesis remain elusive. Using an extensive CRISPR/Cas9-mediated genetic engineering approaches in different prostate cancer cell lines combined with in vivo tumorigenesis studies in mice, bone marrow-on-chip assa...

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Literature Corpus work: ef469a20-4b9f-5183-ac46-646e2183e93a
DOI: 10.1101/2021.11.08.467671

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