Article
Vitamin D receptor (ApaI/BsmI) polymorphisms, human leukocyte antigen-DQB2/DRB3 sub-alleles, and endoplasmic reticulum stress: unravelling their interplay in the pathogenesis of Graves' disease in a tertiary care centre.
Molecular biology reports - 16 Apr 2026
Haldar Akash Kumar, Roy Ajitesh, Dastidar Rinini, Banerjee Shawan Kumar, Talukdar Debdatta, Basu Arnab, Kumar Soumitra, Sikder Kunal
Abstract excerpt
BACKGROUND: Autoimmune thyroid diseases (AITDs), particularly Graves’ disease (GD), are complex disorders characterized by thyroidal immune infiltration and autoantibody production influenced by genetic and environmental factors. HLA class II alleles (HLA-DQB2, HLA-DRB3) promote immune tolerance loss via altered antigen presentation, while vitamin D receptor (VDR) polymorphisms (ApaI-rs7975232; BsmI-rs1544410)...
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