Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization.

doi:10.1097/MD.0000000000036284

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Article

Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization.

Medicine - 8 Dec 2023

Wu Jiayu, Fan Qiaoming, He Qi, Zhong Qian, Zhu Xianqiong, Cai Huilian, He Xiaolin, Xu Ying, Huang Yuxuan, Di Xingwei

Abstract excerpt

Myocardial infarction (MI) is a major cause of death and disability worldwide, but current treatments are limited by their invasiveness, side effects, and lack of efficacy. Novel drug targets for MI prevention are urgently needed. In this study, we used Mendelian randomization to identify potential therapeutic targets for MI using plasma protein quantitative trait loci as exposure variables and MI as the outcome...

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PMID: 38065874
DOI: 10.1097/MD.0000000000036284
PMCID: PMC10713171

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