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Pleiotropic Effects of Polymorphisms in the <em>BCL11A</em> Gene on Laboratory Parameters in Sickle Cell Anemia

2025-09-16

Abstract excerpt

Sickle cell anemia (SCA) is characterized by hematological events that lead to vaso-occlusion and the onset of clinical manifestations. Fetal hemoglobin (HbF) has been shown to positively influence the clinical outcomes of individuals with SCA. Genetic polymorphisms are known to modulate clinical phenotypes by increasing HbF levels, with the BCL11A gene being an important marker in this regard for future therapies...

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Literature Corpus work
40e1a41e-da5f-5e65-b7c1-bf4922588077
DOI
10.20944/preprints202509.1292.v1
Open publication

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Pleiotropic Effects of Polymorphisms in the <em>BCL11A</em> Gene on Laboratory Parameters in Sickle Cell AnemiaDOI 10.20944/preprints202509.1292.v1
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