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Article

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.

JAMA network open - 2 Oct 2023

Kirkham Justin K, Estepp Jeremie H, Weiss Mitch J, Rashkin Sara R

Abstract excerpt

Importance: Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are influenced by additional genetic factors. Despite decades of research, the genetics of SCD remain poorly understood. Objective: To assess all reported genetic modifiers of SCD, evaluate the design of associated studies, and provide guidelines for future analyses according to modern genetic study recommendations. Data Sources:...

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Share to alpha-Thalassemia
Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37851445
DOI: 10.1001/jamanetworkopen.2023.37484
PMCID: PMC10585422

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