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Article

Pharmacological rescue of follicle-stimulating hormone receptor mutants. In vitro and in silico studies.

Endocrinology - 7 Apr 2026

Zariñán Teresa, Jardón-Valadez Eduardo, Gutiérrez-Sagal Rubén, Ulloa-Pérez Ernesto, Nataraja Selvaraj, Yu Henry N, Ulloa-Aguirre Alfredo

Abstract excerpt

Mutations in the follicle-stimulating hormone receptor (FSHR) may result in impaired plasma membrane expression due to misfolding and intracellular retention of the receptor, leading to disease. Rescue of misfolded receptors may be achieved employing pharmacological chaperones (small molecules that specifically bind misfolded proteins, promoting their correct trafficking to their site of action). This study...

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Identifiers

PMID: 41988939
DOI: 10.1210/endocr/bqag045
PMCID: PMC13142252

Genes

FSHR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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