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Article

Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function.

Seminars in reproductive medicine - 1 Sept 2007

Bédécarrats Grégoy Y, Kaiser Ursula B

Abstract excerpt

Pulsatile hypothalamic release of GnRH tightly controls reproduction by activating a specific cell membrane receptor (GnRHR) on the surface of pituitary gonadotrophs to stimulate luteinizing hormone and follicle-stimulating hormone secretion. During the last 10 years, 21 loss-of-function GNRHR mutations have been identified in patients with idiopathic hypogonadotropic hypogonadism. Although most patients with...

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Source

Identifiers

PMID: 17710733
DOI: 10.1055/s-2007-984743

Genes

GNRHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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