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Article

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.

Scientific reports - 29 Jun 2020

Smith Emery, Janovick Jo Ann, Bannister Thomas D, Shumate Justin, Ganapathy Vadivel, Scampavia Louis, Spicer Timothy P

Abstract excerpt

Molecules that correct the folding of protein mutants, restoring their functional trafficking, are called pharmacoperones. Most are clinically irrelevant and possess intrinsic antagonist or agonist activity. Here, we identify compounds capable of rescuing the activity of mutant gonadotropin-releasing hormone receptor or GnRHR which, is sequestered within the cell and if dysfunctional leads to Hypogonadotropic...

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Identifiers

PMID: 32601341
DOI: 10.1038/s41598-020-67473-w
PMCID: PMC7324376

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