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Article

Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome.

Frontiers in endocrinology - 1 Jan 2022

Chen Xiaopan, Chen Linjie, Wang Yang, Shu Chongyi, Zhou Yier, Wu Ruifang, Jin Bihui, Yang Leixiang, Sun Junhui, Qi Ming, Shu Jing

Abstract excerpt

Primary ovarian insufficiency (POI) is among the foremost causes of women infertility due to premature partial or total loss of ovarian function. Resistant ovary syndrome (ROS) is a subtype of POI manifested as normal ovarian reserve but insensitive to gonadotropin stimulation. Inactivating variants of follicle-stimulating hormone receptor (FSHR), a class A G-protein coupled receptor, have been associated with...

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Source

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Identifiers

PMID: 36704038
DOI: 10.3389/fendo.2022.1013894
PMCID: PMC9871476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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