Article
Pharmacoperones for Misfolded Gonadotropin Receptors.
Handbook of experimental pharmacology - 1 Jan 2018
Newton Claire L, Anderson Ross C
Abstract excerpt
The gonadotropin receptors (luteinising hormone receptor; LHR and follicle-stimulating hormone receptor; FSHR) are G protein-coupled receptors (GPCRs) that play an important role in the endocrine control of reproduction. Thus genetic mutations that cause impaired function of these receptors have been implicated in a number of reproductive disorders. Disease-causing genetic mutations in GPCRs frequently result in...
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