Article
The Drosophila melanogaster Genetic Reference Panel.
Nature - 8 Feb 2012
Mackay Trudy F C, Richards Stephen, Stone Eric A, Barbadilla Antonio, Ayroles Julien F, Zhu Dianhui, Casillas Sònia, Han Yi, Magwire Michael M, Cridland Julie M, Richardson Mark F, Anholt Robert R H, Barrón Maite, Bess Crystal, Blankenburg Kerstin Petra, Carbone Mary Anna, Castellano David, Chaboub Lesley, Duncan Laura, Harris Zeke, Javaid Mehwish, Jayaseelan Joy Christina, Jhangiani Shalini N, Jordan Katherine W, Lara Fremiet, Lawrence Faye, Lee Sandra L, Librado Pablo, Linheiro Raquel S, Lyman Richard F, Mackey Aaron J, Munidasa Mala, Muzny Donna Marie, Nazareth Lynne, Newsham Irene, Perales Lora, Pu Ling-Ling, Qu Carson, Ràmia Miquel, Reid Jeffrey G, Rollmann Stephanie M, Rozas Julio, Saada Nehad, Turlapati Lavanya, Worley Kim C, Wu Yuan-Qing, Yamamoto Akihiko, Zhu Yiming, Bergman Casey M, Thornton Kevin R, Mittelman David, Gibbs Richard A
Abstract excerpt
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic...
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