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Article

The mouse Engrailed-1 gene and ventral limb patterning.

Nature - 25 Jul 1996

Loomis C A, Harris E, Michaud J, Wurst W, Hanks M, Joyner A L

Abstract excerpt

During vertebrate limb development, positional information must be specified along three distinct axes. Although much progress has been made in our understanding of the molecular interactions involved in anterior-posterior and proximal-distal limb patterning, less is known about dorsal-ventral patterning. The genes Wnt-7a and Lmx-1, which are expressed in dorsal limb ectoderm and mesoderm, respectively, are...

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Identifiers

PMID: 8684466
DOI: 10.1038/382360a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The mouse Engrailed-1 gene and ventral limb patterning.PMID 8684466Read ↗

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Temporal loss of En1 during limb development causes distinct phenotypes.Semantic proximity Read ↗

Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.Semantic proximity Read ↗

The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud.Semantic proximity Read ↗

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.Semantic proximity Read ↗

Multiple roles of mesenchymal beta-catenin during murine limb patterning.Semantic proximity Read ↗

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