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Article

Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.

PloS one - 1 Jan 2015

Huettl Rosa-Eva, Luxenhofer Georg, Bianchi Elisa, Haupt Corinna, Joshi Rajiv, Prochiantz Alain, Huber Andrea B

Abstract excerpt

Engrailed-1 (En1) is expressed in the ventral ectoderm of the developing limb where it plays an instructive role in the dorsal-ventral patterning of the forelimb. Besides its well-described role as a transcription factor in regulating gene expression through its DNA-binding domain, En1 may also be secreted to form an extracellular gradient, and directly impact on the formation of the retinotectal map. We show...

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Source

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Identifiers

PMID: 25710467
DOI: 10.1371/journal.pone.0118505
PMCID: PMC4340014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Engrailed 1 mediates correct formation of limb innervation through two distinct mechanisms.PMID 25710467Read ↗

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