Article
Chloroquine resistant P. falciparum prevalence is low and unchanged between 1990 and 2005 in Guinea-Bissau: an effect of high chloroquine dosage?
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Sept 2007
Ursing Johan, Schmidt Berit Aydin, Lebbad Marianne, Kofoed Poul-Erik, Dias Fransisco, Gil José Pedro, Rombo Lars
Abstract excerpt
Chloroquine resistant malaria was first reported in Guinea-Bissau in 1990 but chloroquine remains the most commonly used antimalarial in the country. Since 1990, we have conducted nearly annual standardized WHO in vitro micro-tests to assess chloroquine resistance. We have identified pfcrt 76T and other genetic polymorphisms in samples from 1992, 1993, 1995, 2004 and 2005. We have also monitored drug...
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