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Frequency of bilateral prophylactic and contra-lateral risk-reducing mastectomies in women with germline PALB2 variants.

Familial cancer - 15 Apr 2026

Corso Giovanni, La Vecchia Carlo, Polizzi Andrea, Magnoni Francesca, Abruzzese Giuliarianna, Di Silvestre Susanna, Pesapane Filippo, Nicosia Luca, Bogani Giorgio, Intra Mattia, Veronesi Paolo, Galimberti Viviana

Abstract excerpt

Germline PALB2 variants confer a moderate/high-risk for breast cancer (BC). Recent reports described an increasing attention in suggesting bilateral prophylactic mastectomy (BPM), for healthy carriers, or contraleral risk-reducing mastectomy (CRRM) and/or therapeutic mastectomy for women with BC. In this study, we aimed to calculate systematically the overall number of these procedures reported in literature. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41984324
DOI: 10.1007/s10689-026-00554-3

Genes

PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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