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Article

B-Acute Lymphoblastic Leukemia Masquerading as Multifocal Langerhans Cell Histiocytosis: a Diagnostic Paradigm Shift.

Clinical laboratory - 1 Apr 2026

Xiao Dejun, Liao Hong, Peng Fang, Wen Xinglin, Liu Zhiqing

Abstract excerpt

BACKGROUND: This report describes a diagnostically challenging case of B-cell acute lymphoblastic leukemia (B-ALL) perfectly mimicking multifocal Langerhans cell histiocytosis (LCH), revealing a critical diagnostic pitfall in pediatric oncology. METHODS: A 6-year-old girl presented with progressive back pain. MRI showed multilevel vertebral collapse (T11-L2) with classic LCH features, while PET-CT revealed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histiocytosis, Langerhans-Cell

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Share to Magnetic Resonance Imaging

Share to Positron Emission Tomography Computed Tomography

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 41979620
DOI: 10.7754/Clin.Lab.2025.250657

Genes

KRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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