Adult-onset Langerhans cell histiocytosis of bone: A case series highlighting a rare entity.

doi:10.1016/j.anndiagpath.2023.152171

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Article

Adult-onset Langerhans cell histiocytosis of bone: A case series highlighting a rare entity.

Annals of diagnostic pathology - 1 Oct 2023

Javadi Tiffany, Hill Charles, McLemore Morgan Lee, Oskouei Shervin, Bahrami Armita

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a neoplastic disorder derived from LCH precursor cells that can manifest as a single-system disease or a multisystem disorder. While extensively studied in children, LCH has received less attention in adult patients. We aimed to investigate the pathology and clinical course of LCH in adults presenting with a bone lesion. Cases of osseous LCH diagnosed in patients ≥18 in our...

Topics

Male
Child
Female
Humans
Adult
Adolescent
Young Adult
Middle Aged
Aged
Proto-Oncogene Proteins B-raf
Histiocytosis, Langerhans-Cell
Neoplasms
Bone and Bones
Mutation

Source

Open in PubMed

Identifiers

PMID: 37295039
DOI: 10.1016/j.anndiagpath.2023.152171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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