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Article

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging-Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Mar 2026

Chen Jinbin, Wang Xin, Ding Haifeng, Zheng Bosheng, Zeng Keni, Hu Chuying, Liu Jiayi, Zhu Xiao, Yu Haibing

Abstract excerpt

Autoimmune inflammatory diseases (AIDs) are genetically linked disorders with unclear causal links to brain functional networks. Using bidirectional two-sample Mendelian randomization (MR) on GWAS data from 18 AIDs and 1,366 brain imaging-derived phenotypes (n = 8,428), we identified significant associations, including reduced left striatal activity increasing multiple sclerosis risk (OR = 0.59), left uncinate...

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PMID: 41449770
DOI: 10.1002/advs.202515675
PMCID: PMC12970252

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