Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of PD-1 gene polymorphisms and serum soluble PD-1 levels with type 1 diabetes mellitus susceptibility in a Chinese Han cohort: a case-control study.

Frontiers in immunology - 1 Jan 2026

Zhao Renhao, Feng Xiuli, Wang Na, Wang Zijing, Liu Jing, Wang Guofeng

Abstract excerpt

Background: The programmed cell death 1 (PD-1)/PD-L1 pathway plays a critical role in immune tolerance and has been implicated in type 1 diabetes mellitus (T1DM). However, the associations between PD-1 polymorphisms, circulating soluble PD-1 (sPD-1), and T1DM susceptibility remain unclear in Chinese populations. This study evaluated the relationships of PD-1 rs2227981 and rs2227982 variants and serum sPD-1 levels...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles
Share to Case-Control Studies
Share to China
Share to Diabetes Mellitus, Type 1
Share to East Asian People
Share to Gene Frequency
Share to Genetic Association Studies
Share to Programmed Cell Death 1 Receptor

Source

Open in PubMed Open full text

Identifiers

PMID: 41972147
DOI: 10.3389/fimmu.2026.1783770
PMCID: PMC13066176

Genes

TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of PD-1 gene polymorphisms and serum soluble PD-1 levels with type 1 diabetes mellitus susceptibility in a Chinese Han cohort: a case-control study.PMID 41972147Read ↗

Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes SusceptibilitySemantic proximity Read ↗

Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.Semantic proximity Read ↗

Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian.Semantic proximity Read ↗

PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children.Semantic proximity Read ↗

The association of polymorphisms (rs2227981 and rs10204525) of PDCD1 gene with susceptibility to human T-cell leukemia virus type 1.Semantic proximity Read ↗

Clinical and HLA genotype analysis of immune checkpoint inhibitor-associated diabetes mellitus: a single-center case series from China.Semantic proximity Read ↗

PD-L1 gene polymorphisms and low serum level of PD-L1 protein are associated to type 1 diabetes in Chile.Semantic proximity Read ↗

Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes.Semantic proximity Read ↗

Effects of the programmed cell death 1 (PDCD1) polymorphisms in susceptibility to systemic lupus erythematosusSemantic proximity Read ↗

PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population.Semantic proximity Read ↗

Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.Semantic proximity Read ↗

CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.