Article
Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.
Annals of the New York Academy of Sciences - 1 Oct 2006
Hiromine Yoshihisa, Ikegami Hiroshi, Fujisawa Tomomi, Kawabata Yumiko, Noso Shinsuke, Yamaji Kaori, Asano Katsuaki, Ogihara Toshio
Abstract excerpt
Multiple genes are involved in the susceptibility to autoimmune type 1 diabetes. The immunoreceptor programmed cell death-1 (PDCD-1), an inhibitory costimulatory molecule regulating peripheral tolerance, was reported to play a role in the development of type 1 diabetes, making the human PDCD-1 gene, PDCD1, as a candidate for disease susceptibility. In this article, we sequenced all 5 exons and exon-intron...
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