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Article

PDX1 and MC4R genetic polymorphisms are associated with type 2 diabetes mellitus risk in the Chinese Han population.

BMC medical genomics - 25 Oct 2021

Wang Ning, Tong Rui, Xu Jing, Tian Yanni, Pan Juan, Cui Jiaqi, Chen Huan, Peng Yanqi, Fei Sijia, Yang Shujun, Wang Lu, Yao Juanchuan, Cui Wei

Abstract excerpt

BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disease that is caused by a complex interplay between genetic and environmental factors. This research aimed to investigate the association of genetic polymorphisms in PDX1 and MC4R with T2DM risk. METHODS: The genotypes of 10 selected SNPs in PDX1 and MC4R were identified using the Agena MassARRAY platform. We utilized odds ratio (OR) and 95% confidence...

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PMID: 34696776
DOI: 10.1186/s12920-021-01037-3
PMCID: PMC8543917

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