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Article

Host-microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency.

Nature metabolism - 1 Aug 2024

Lee Yong-Uk, Fox Bennett W, Guo Rui, Curtis Brian J, Yu Jingfang, Kim Sookyung, Nanda Shivani, Baumann Victor, Yilmaz L Safak, Haynes Cole M, Schroeder Frank C, Walhout Albertha J M

Abstract excerpt

In humans, defects in leucine catabolism cause a variety of inborn errors in metabolism. Here, we use Caenorhabditis elegans to investigate the impact of mutations in mccc-1, an enzyme that functions in leucine breakdown. Through untargeted metabolomic and transcriptomic analyses we find extensive metabolic rewiring that helps to detoxify leucine breakdown intermediates via conversion into previously undescribed...

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PMID: 39117959
DOI: 10.1038/s42255-024-01098-5
PMCID: PMC11670331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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