Article
Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.
Blood - 8 Sept 2016
Elena Chiara, Gallì Anna, Such Esperanza, Meggendorfer Manja, Germing Ulrich, Rizzo Ettore, Cervera Jose, Molteni Elisabetta, Fasan Annette, Schuler Esther, Ambaglio Ilaria, Lopez-Pavia Maria, Zibellini Silvia, Kuendgen Andrea, Travaglino Erica, Sancho-Tello Reyes, Catricalà Silvia, Vicente Ana I, Haferlach Torsten, Haferlach Claudia, Sanz Guillermo F, Malcovati Luca, Cazzola Mario
Abstract excerpt
Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm with variable clinical course. To predict the clinical outcome, we previously developed a CMML-specific prognostic scoring system (CPSS) based on clinical parameters and cytogenetics. In this work, we tested the hypothesis that accounting for gene mutations would further improve risk stratification of CMML patients. We...
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